Israeli scientists successfully used CRISPR gene-editing technology to develop a nutrient-enhanced variety of lettuce, marking a breakthrough in efforts to combat global micronutrient deficiencies.

Nutrient deficiencies, often referred to as “hidden hunger,” affect millions of people worldwide, particularly in regions where access to diverse, nutrient-rich foods is limited. Hidden hunger refers to a form of malnutrition where individuals suffer from deficiencies in essential micronutrients despite having enough calories to meet their basic energy needs. It is not immediately visible because people may appear well-nourished in terms of body weight, but their bodies lack crucial nutrients that are necessary for proper growth, immune function, and overall health.

The newly developed lettuce variety contained 2.7 times more β-carotene (provitamin A), an essential compound for vision, immune function, and skin health. It also boasted higher levels of zeaxanthin, a powerful antioxidant that protects against blue light damage and age-related macular degeneration, as well as a remarkable 6.9-fold increase in ascorbic acid (vitamin C), which supports immune function and enhances iron absorption.

These enhancements were achieved by modifying key genes that regulate vitamin and antioxidant production, allowing for multiple nutritional improvements simultaneously rather than targeting a single nutrient, the researchers explained.

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