Milan reshuffle the defence and midfield, but it’s the first choice attack with Rafael Leao and Olivier Giroud for the Europa League play-off with Rennes.
It kicks off at San Siro at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Feyenoord-Roma on the LIVEBLOG.
The second leg is next Thursday and will decide who goes through to the Europa League Round of 16.
Milan dropped down from the Champions League and Rennes finished second in their Europa League group, though their form has picked up considerably recently with eight consecutive wins in all competition.
Davide Calabria, Fikayo Tomori, Pierre Kalulu and Tommaso Pobega are injured, with Samuel Chukwueze not back yet from Africa Cup of Nations duty.
Tijjani Reijnders was suspended in Serie A at the weekend, so he returns with Yunus Musah giving Ismael Bennacer and Yacine Adli a rest.
Simon Kjaer can start despite a few fitness concerns, with Alessandro Florenzi at right-back and Malick Thiaw on the bench after a three-month absence.
Rennes are missing Fabian Rieder and Enzo Le Fée, but can rely on former Bologna defender Arthur Theate and veteran goalkeeper Steve Mandanda, who turns 39 next month.
Milan: Maignan; Florenzi, Kjaer, Gabbia, Theo Hernandez; Musah, Reijnders; Pulisic, Loftus-Cheek, Rafael Leao; Giroud
Rennes: Mandanda; G Doue, Omari, Theate, Truffert; Bourigeaud, Matusiwa, Santamaria, D Doue; Terrier, Kalimuendo
Ref: Dabanovic (MNE)
| Ruben Loftus-Cheek (Assist: Alessandro Florenzi) |  | 32' |
| Ruben Loftus-Cheek | | 47' | ||
| Rafael Leão (Assist: Theo Hernández) | | 53' | ||
| 87' |  | Mahamadou Nagida |
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