Although many ultra-processed foods—soda, candy, energy bars, fruit-flavored yogurt, frozen pizza, and frozen meals—can satisfy cravings for sweet, fatty, salty foods, emerging research suggests these items are particularly bad for the brain—with mood and cognition taking a hit.

Diets high in these foods were linked to a 44 percent greater risk of depression and a 48 percent higher risk of anxiety, according to a meta-analysis published in the journal Nutrients. In one of these studies, risk rose from consuming just 33 percent of calories from ultra-processed food. A separate study from Brazil that tracked 10,775 people found that taking in just 20 percent of calories from these foods was linked to a 28 percent faster rate of cognitive decline compared with people who ate less processed food.

Processed foods can be healthy, it’s the ultra-processed items that are linked to poor health. What’s the difference? Very generally, ultra-processed foods use ingredients not found in a home kitchen. A more precise description comes from the NOVA classification system.

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