The first gene-edited pig organs ever transplanted into people came from animals born on this special research farm in the Blue Ridge mountains – behind locked gates, where entry requires washing down your vehicle, swapping your clothes for medical scrubs and stepping into tubs of disinfectant to clean your boots between each air-conditioned barn.

“These are precious animals,” said David Ayares of Revivicor Inc., who spent decades learning to clone pigs with just the right genetic changes to allow those first audacious experiments.

The biosecurity gets even tighter just a few miles away in Christiansburg, Virginia, where a new herd is being raised – pigs expected to supply organs for formal studies of animal-to-human transplantation as soon as next year.

This massive first-of-its-kind building bears no resemblance to a farm. It’s more like a pharmaceutical plant.

But in neighboring Christiansburg is the clearest signal that xenotransplantation is entering a new phase — the sheer size of United Therapeutics’ new pathogen-free facility. Inside the 77,000-square-foot building, the company expects to produce about 125 pig organs a year, likely enough to supply clinical trials.

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